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Humboldt-Universität zu Berlin - LARKUM LAB




Seibt, J., Richard, C.J., Sigl-Glöckner, J., Takahashi, N., Kaplan, D., Doron, G., de Limoges, D., Bocklisch, C., Larkum, M.E. (2017) Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents. Nature Communications in press 


Suzuki, M., Larkum, M.E. (2017) Dendritic calcium spikes are clearly detectable at the cortical surface. Nature Communications 8, 276. DOI: 10.1038/s41467-017-00282-4


Zolnik TA, Sha F, Johenning FW, Schreiter ER, Looger LL, Larkum ME, Sachdev RN. (2017) All-optical functional synaptic connectivity mapping in acute brain slices using the calcium integrator CaMPARI . J Physiol595: 1465-1477. doi: 10.1113/JP273116


Micaller, A.F., Takahashi, N., Larkum, M.E., Palmer, L.M. (2017) A reward-based behavioral platform to measure neuronal activity during head-fixed behavior. Frontiers in Cellular Neuroscience. doi: 10.3389/fncel.2017.00156


Nashaat MA, Oraby H, Peña LB, Dominiak S, Larkum ME, Sachdev RN. (2017) Pixying Behavior: A Versatile Real-Time and Post Hoc Automated Optical Tracking Method for Freely Moving and Head Fixed Animals. eNeuro 4: ENEURO.0245-16. doi: 10.1523/ENEURO.0245-16.2017




Naoya Takahashi, Thomas G. Oertner, Peter Hegemann, Matthew E. Larkum. (2016) Active Cortical Dendrites Modulate Perception. Science 354: 1587-1590. Doi: 10.1126/science.aah6066


Ebbesen C.L., Doron G., Lenschow C., Brecht M. (2016) Vibrissa motor cortex activity suppresses contralateral whisker movement. Nat. Neurosci. 2016 Oct 31. doi: 10.1038/nn.4437


Doose J.(1), Doron G.(1)*, Brecht M., Lindner B.* (2016) Noisy juxtacellular stimulation in vivo leads to reliable spiking and reveals high-frequency coding in single neurons. J. Neurosci. 36 (43): 11120-11132.


Phillips, W.A., Larkum, M.E., Harley, C.W., Silverstein, S.M. (2016) The effects of arousal on apical amplification and conscious state. Neuroscience of Consciousness 2016:niw015


Sean C Murphy, Lucy M Palmer, Thomas Nyffeler, René M Müri, Matthew E Larkum. (2016) Transcranial magnetic stimulation (TMS) inhibits cortical dendrites. eLife pii: e13598. doi: 10.7554/eLife.13598


Nashaat, M.A., Oraby, H., Sachdev, R.N.S., Winter, Y., Larkum, M.E. (2016) A real-world floating environment for active sensing in head-fixed mice. J Neurophysiology 116: 1542-1553




Mayrhofer, J.M., Haiss, F., Haenni, D., Weber, S., Zuend, M., Barrett, M.J., Ferrari, K.D., Maechler, P., Saab, A.S., Stobart, J.L., Wyss, M.T., Johannssen, H., Osswald, H., Palmer, L.M., Revol, V., Schuh, C.D., Urban, C., Hall, A., Larkum, M.E., Rutz-Innerhofer, E., Zeilhofer, H.U., Ziegler, U., Weber, B. (2015) Design and performance of an ultra-flexible two-photon microscope for in vivo research. Biomed Opt Express 6: 4228-4237


Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., Ota, K., Matsubara, C., Inutsuka, A., Sato, M., Ohkura, M., Yamanaka, A., Yanagawa, Y., Nakai, J., Hayashi, Y., Larkum, M.E., Murayama, M. (2015) A top-down cortical circuit for accurate sensory perception. Neuron 86: 1304-1316


Shai, A.S., Anastassiou, C.A., Larkum, M.E., Koch, C. (2015) Physiology of layer 5 pyramidal neurons in mouse primary visual cortex: coincidence detection through bursting. PLoS Computational Biology 11, doi: 10.1371/journal.ocbi.1004090




Murayama, M., Larkum, M.E. (2014) In vivo population imaging of dendritic integration in neocortex. In Optical Imaging of Neocortical Dynamics. Weber, B., Helmchen, F. eds. 107-116.


Palmer, L.M., Shai, A.S., Reeve, J.E., Anderson, H.L., Paulsen, O., Larkum, M.E. (2014) NMDA spikes enhance action potential generation during sensory input. Nature Neuroscience 17: 383-390.




Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. (2013) The challenge of connecting the dots in the B.R.A.I.N. Neuron 80: 270-274.


Palmer, L.M., Schulz, J.M., Larkum, M.E. (2013) Layer-specific regulation of cortical neurons by interhemispheric inhibition. Commun Integr Biol 6: e23545.


Game changing results: Brain uses the cortex for making sensory associations, not the hippocampus. Max Planck Institute for Medical Research Press Release


Mazahir T. Hasan, Samuel Hernández-González, Godwin Dogbevia, Mario Treviño, Ilaria Bertocchi, Agnès Gruart & José M. Delgado-García (2013) Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice. Nature Comunications 4: 2258


Hamilton, T., Xapelli, S., Michaelson, S., Larkum, M., Colmers, W. (2013) Modulation of distal calcium electrogenesis by neuropeptide Y1 receptors inhibits neocortical long-term depression. Journal of Neuroscience 33(27) 11185-11193.


Larkum, M. (2013) A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex. Trends in Neurosciences 36: 141-151.


Larkum, M.E. (2013) The yin and yang of cortical layer 1. Nature Neuroscience 16: 114-115.


Major, G., Larkum, M.E.*, Schiller, J.* (2013) Active properties of neocortical pyramidal neuron dendrites. Annual Reviews Neuroscience. 36: 1-24. * Equal contribution


Pérez-Garci, E., Larkum, M.E., Nevian, T. (2013) Inhibition of dendritic Ca2+ spikes by GABAB receptors in cortical pyramidal neurons is mediated by a direct Gi/o-bg subunit interaction with Cav1 channels. J. Physiol. 591: 1599-1612.




Palmer, L.M., Schulz, J.M., Murphy, S.C., Ledergerber, D., Murayama, M. & Larkum, M.E. (2012) The cellular basis of GABAB-mediated interhemispheric inhibition. Science 335: 989-993.


Schoen, A., Salehiomran, A., Larkum, M.E., Cook, E.P. (2012) A compartmental model of linear resonance and signal transfer in dendrites. Neural Computation 24:3126-3144.


Palmer, L.M., Murayama, M. & Larkum, M.E. (2012) Inhibitory regulation of dendritic activity in vivo. Frontiers in Neural Circuits. doi:10.3389.


Granato, A., Palmer, L.M., De Giorgio, A., Tavian, D., and Larkum, M.E. (2012). Early exposure to alcohol leads to a permanent impairment of dendritic excitability in neocortical pyramidal neurons. J. Neurosci. 32(4): 1377-1382


Murayama, M. & Larkum, M.E. (2012) Fiber-optic calcium monitoring of dendritic activity in vivo. Cold Spring Harb Protoc 2012: 218-225.


Ledergerber, D. & Larkum, M.E. (2012) The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex. PLoS one 7: e33146.


Granato, A., Palmer, L.M., De Giorgio, A., Tavian, D., Larkum, M.E. (2012) Early exposure to alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal neurons. J Neurosci. 32: 1377-1282.


William N Ross, Matthew Larkum (2012). Dendrites. Wiley Online Library. DOI: 10.1002/9780470015902.a0000092.pub3




Murayama, M. & Larkum, M.E. (2011) Fiber-optic calcium monitoring of dendritic activity in vivo. In Imaging in Neuroscience: A Laboratory Manual. Helmchen, F., Konnerth, A., eds. 897-906.




Hamilton, T.J., Wheatley, B.M., Sinclair, D.B., Bachmann, M., Larkum, M.E., Colmers, W.F. (2010) Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells. PNAS 107: 18185-18190.


Ledergeber, D. & Larkum, M.E. (2010) Properties of L6 pyramidal neuron apical dendrites. J Neurosci. 30: 13031-13044


Lütcke, H., Murayama, M., Hahn, T., Margolis, D.J., Astori, S., Meyer zum Alten Borgloh, S., Göbel, W., Yang, Y., Tang, W., Kügler, S., Sprengel, R., Nagai, T., Miyawaki, A., Larkum, M.E., Helmchen, F., & Hasan, M.T. (2010) Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Frontiers in Neuroscience. 4-9.




Murayama, M. & Larkum, M.E. (2009) Enhanced dendritic activity in awake rats. PNAS, 106: 20482-20486.


Bathellier, B., Margrie, T.W. & Larkum, M.E. (2009) Properties of piriform cortex pyramidal cell dendrites: implications for olfactory circuit design. Journal of Neuoscience, 29: 12641-12652.


Murayama, M. & Larkum, M.E. (2009) In vivo dendritic calcium imaging with a fiberoptic periscope system. Nature Protocols, 4: 1551-1559.


Larkum, M.E.*, Nevian, T*., Sandler, M., Polsky, A., & Schiller, J. (2009) Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science, 325: 756-760.
* Equal contribution


Murayama, M., Pérez-Garci, E., Nevian, T., Bock, T., Senn, W., & Larkum, M.E. (2009) Dendritic encoding of sensory stimuli controlled by deep cortical interneurons. Nature, 457: 1137-1141.




London, M., Larkum, M.E., & Häusser, M. (2008) Predicting the synaptic information efficacy in cortical layer 5 pyramidal neurons using a minimal Integrate-and-Fire model. Biological Cybernetics, 99: 393-401.


Larkum, M.E. & Nevian, T. (2008) Synaptic clustering by dendritic signaling mechanisms. Current Opinion in Neurobiology. 18: 1-11.


Potez, S. & Larkum, M.E. (2008) Effect of common anesthetics on dendritic calcium spike firing in layer 5 neocortical pyramidal neurons. Journal of Neurophysiology, 99: 1394-1407.


Larkum, M.E., Watanabe, S., Lasser-Ross, N., Rhodes, P., & Ross, W.N. (2008) Dendritic properties of turtle pyramidal neurons. Journal of Neurophysiology, 99: 683-694.




Larkum, M.E., Waters, J., Sakmann, B., Helmchen, F. (2007) Dendritic spikes in apical dendrites of neocortical layer 2/3 pyramidal neurons. Journal of Neuroscience, 27: 8999-9008.


Murayama, M., Pérez-Garci, E., Lüscher, H.-R., Larkum, M.E. (2007) Fiberoptic system for recording dendritic calcium signals in layer 5 neocortical pyramidal cells in freely moving rats. Journal of Neurophysiology, 98: 1791-1805.


Nevian, T.*, Larkum, M.E.*, Polsky, A., Schiller, J. (2007) Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nature Neuroscience, 10: 206-214. * Equal contribution




Pérez-Garci, E., Gassmann, M., Bettler, B., and Larkum, M.E. (2006) The GABAB1b isoform mediates long-lasting inhbition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron, 50: 603-616.




Ross, W.N., Nakamura, T., Watanabe, S., Larkum, M., Lasser-Ross, N. (2005) Synaptically activated Ca2+ release from internal stores in CNS neurons. Cellular and Molecular Neurobiology, 25: 283-285.




Larkum, M.E., Senn, W, and Lüscher, H.-R. (2004). Top-down dendritic input increases the gain of layer 5 pyramidal neurons. Cerebral Cortex, 10: 1059-70.


Hasan, M.T., Friedrich, R.W., Euler, T., Larkum, M.E., Giese, G., Both, M., Duebel, J., Waters, J., Bujard, H., Griesbeck, O., Tsien, R.Y., Nagai, T., Miyawaki, A., Denk, W. (2004) Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control. PLoS Biol. 2: 763-775.


Larkum, M.E., Watanabe, S., Nakamura, T., Lasser-Ross, N., and Ross, W.N. (2003). Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons. Journal of Physiology 549: 471-488.




Schaefer, A.T., Larkum, M.E., Sakmann, B. & Roth, A. (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. Journal of Neurophysiology 89: 3143-3154.


Waters, J., Larkum, M.E., Sakmann, B. & Helmchen, F. (2003) Supralinear Ca2+ influx into dendritic tufts of layer 2/3 neocortical pyramidal neurons in vitro and in vivo. Journal of Neuroscience 23: 8558-8567.




Larkum, M.E. & Zhu, J.J. (2002) Distal and terminal dendrites of rat layer 5 pyramidal neocortical neurons: initiation and propagation of action potentials in apical tuft branches.  Journal of Neuroscience 22: 6991-7005.


London, M., Shribman, A., Häusser, M., Larkum, M.E., Segev, I. (2002)  Synaptic information efficacy: Bridging the cleft between biophysics and function. Nature Neuroscience 5: 332-340.




Larkum, M.E., Zhu, J.J., Sakmann, B. (2001) Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons. Journal of Physiology 533: 447-466.




Berger, T.*, Larkum, M.E.*  and Lüscher, H.-R.  (2000)  A high Ih channel density in the distal apical dendrite of layer V neocortical pyramidal cells increases bidirectional attenuation of EPSPs. Journal of Neurophysiology 85: 855-868.

* Equal contribution




Larkum, M.E., Kaiser, K.M.M., Sakmann, B. (1999b)  Calcium electrogenesis in distal apical dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action potentials.  PNAS. 96: 14600-14604.


Larkum, M.E., Zhu, J.J., Sakmann, B. (1999a)  A new mechanism for coupling inputs arriving at different cortical layers.  Nature. 398: 338-341.




Larkum, M.E., Launey, J., Dityatev, A., Lüscher, H.-R. (1998).  Integration of excitatory postsynaptic potentials in dendrites of motoneurons of rat spinal cord slice cultures.  Journal of Neurophysiology.  80, 924-935


Lüscher, H.-R. & Larkum, M.E. (1998).  Modeling action potential initiation and back-propagation in dendrites of cultured rat motoneurons.  Journal of Neurophysiology  80, 715-729 (1998).




Larkum, M.E., Rioult, M.G., Lüscher, H.-R. (1996).  Propagation of action potentials in the dendrites of neurons from rat spinal cord slice cultures.  Journal of Neurophysiology.  Vol. 75: 154-170.


Senn, W., Wyler, K., Streit, J., Larkum, M.E., Lüscher, H.-R., Merz, F., Mey, H., Müller, L., Steinhauser, D., Vogt, K. and Wannier, T. (1996). Dynamics of a random neural network with synaptic depression. Neural Networks. 9: 575-588.




Larkum, M.E., Warren, D.A., Bennett, M.R. (1994). Calcium concentration changes in the calyciform nerve terminal of the avian ciliary ganglion after tetanic stimulation. Journal of the Autonomic Nervous System. 46: 175-188.