
Publications
Publications
2018
2017
2016
2015
Mayrhofer, J.M., Haiss, F., Haenni, D., Weber, S., Zuend, M., Barrett, M.J., Ferrari, K.D., Maechler, P., Saab, A.S., Stobart, J.L., Wyss, M.T., Johannssen, H., Osswald, H., Palmer, L.M., Revol, V., Schuh, C.D., Urban, C., Hall, A., Larkum, M.E., Rutz-Innerhofer, E., Zeilhofer, H.U., Ziegler, U., Weber, B. (2015) Design and performance of an ultra-flexible two-photon microscope for in vivo research. Biomed Opt Express 6: 4228-4237
Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., Ota, K., Matsubara, C., Inutsuka, A., Sato, M., Ohkura, M., Yamanaka, A., Yanagawa, Y., Nakai, J., Hayashi, Y., Larkum, M.E., Murayama, M. (2015) A top-down cortical circuit for accurate sensory perception. Neuron 86: 1304-1316
Shai, A.S., Anastassiou, C.A., Larkum, M.E., Koch, C. (2015) Physiology of layer 5 pyramidal neurons in mouse primary visual cortex: coincidence detection through bursting. PLoS Computational Biology 11, doi: 10.1371/journal.ocbi.1004090
2014
Murayama, M., Larkum, M.E. (2014) In vivo population imaging of dendritic integration in neocortex. In Optical Imaging of Neocortical Dynamics. Weber, B., Helmchen, F. eds. 107-116.
Palmer, L.M., Shai, A.S., Reeve, J.E., Anderson, H.L., Paulsen, O., Larkum, M.E. (2014) NMDA spikes enhance action potential generation during sensory input. Nature Neuroscience 17: 383-390.
2013
Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. (2013) The challenge of connecting the dots in the B.R.A.I.N. Neuron 80: 270-274.
Palmer, L.M., Schulz, J.M., Larkum, M.E. (2013) Layer-specific regulation of cortical neurons by interhemispheric inhibition. Commun Integr Biol 6: e23545.
Hamilton, T., Xapelli, S., Michaelson, S., Larkum, M., Colmers, W. (2013) Modulation of distal calcium electrogenesis by neuropeptide Y1 receptors inhibits neocortical long-term depression. Journal of Neuroscience 33(27) 11185-11193.
Larkum, M.E. (2013) The yin and yang of cortical layer 1. Nature Neuroscience 16: 114-115.
Major, G., Larkum, M.E.*, Schiller, J.* (2013) Active properties of neocortical pyramidal neuron dendrites. Annual Reviews Neuroscience. 36: 1-24. * Equal contribution
Pérez-Garci, E., Larkum, M.E., Nevian, T. (2013) Inhibition of dendritic Ca2+ spikes by GABAB receptors in cortical pyramidal neurons is mediated by a direct Gi/o-bg subunit interaction with Cav1 channels. J. Physiol. 591: 1599-1612.
2012
Schoen, A., Salehiomran, A., Larkum, M.E., Cook, E.P. (2012) A compartmental model of linear resonance and signal transfer in dendrites. Neural Computation 24:3126-3144.
Palmer, L.M., Murayama, M. & Larkum, M.E. (2012) Inhibitory regulation of dendritic activity in vivo. Frontiers in Neural Circuits. doi:10.3389.
Granato, A., Palmer, L.M., De Giorgio, A., Tavian, D., and Larkum, M.E. (2012). Early exposure to alcohol leads to a permanent impairment of dendritic excitability in neocortical pyramidal neurons. J. Neurosci. 32(4): 1377-1382
Murayama, M. & Larkum, M.E. (2012) Fiber-optic calcium monitoring of dendritic activity in vivo. Cold Spring Harb Protoc 2012: 218-225.
Ledergerber, D. & Larkum, M.E. (2012) The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex. PLoS one 7: e33146.
Granato, A., Palmer, L.M., De Giorgio, A., Tavian, D., Larkum, M.E. (2012) Early exposure to alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal neurons. J Neurosci. 32: 1377-1282.
William N Ross, Matthew Larkum (2012). Dendrites. Wiley Online Library. DOI: 10.1002/9780470015902.a0000092.pub3
2011
Murayama, M. & Larkum, M.E. (2011) Fiber-optic calcium monitoring of dendritic activity in vivo. In Imaging in Neuroscience: A Laboratory Manual. Helmchen, F., Konnerth, A., eds. 897-906.
2010
Hamilton, T.J., Wheatley, B.M., Sinclair, D.B., Bachmann, M., Larkum, M.E., Colmers, W.F. (2010) Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells. PNAS 107: 18185-18190.
Ledergeber, D. & Larkum, M.E. (2010) Properties of L6 pyramidal neuron apical dendrites. J Neurosci. 30: 13031-13044
Lütcke, H., Murayama, M., Hahn, T., Margolis, D.J., Astori, S., Meyer zum Alten Borgloh, S., Göbel, W., Yang, Y., Tang, W., Kügler, S., Sprengel, R., Nagai, T., Miyawaki, A., Larkum, M.E., Helmchen, F., & Hasan, M.T. (2010) Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Frontiers in Neuroscience. 4-9.
2009
Murayama, M. & Larkum, M.E. (2009) Enhanced dendritic activity in awake rats. PNAS, 106: 20482-20486.
Bathellier, B., Margrie, T.W. & Larkum, M.E. (2009) Properties of piriform cortex pyramidal cell dendrites: implications for olfactory circuit design. Journal of Neuoscience, 29: 12641-12652.
Murayama, M., Pérez-Garci, E., Nevian, T., Bock, T., Senn, W., & Larkum, M.E. (2009) Dendritic encoding of sensory stimuli controlled by deep cortical interneurons. Nature, 457: 1137-1141.
2008
London, M., Larkum, M.E., & Häusser, M. (2008) Predicting the synaptic information efficacy in cortical layer 5 pyramidal neurons using a minimal Integrate-and-Fire model. Biological Cybernetics, 99: 393-401.
Potez, S. & Larkum, M.E. (2008) Effect of common anesthetics on dendritic calcium spike firing in layer 5 neocortical pyramidal neurons. Journal of Neurophysiology, 99: 1394-1407.
Larkum, M.E., Watanabe, S., Lasser-Ross, N., Rhodes, P., & Ross, W.N. (2008) Dendritic properties of turtle pyramidal neurons. Journal of Neurophysiology, 99: 683-694.
2007
Larkum, M.E., Waters, J., Sakmann, B., Helmchen, F. (2007) Dendritic spikes in apical dendrites of neocortical layer 2/3 pyramidal neurons. Journal of Neuroscience, 27: 8999-9008.
Murayama, M., Pérez-Garci, E., Lüscher, H.-R., Larkum, M.E. (2007) Fiberoptic system for recording dendritic calcium signals in layer 5 neocortical pyramidal cells in freely moving rats. Journal of Neurophysiology, 98: 1791-1805.
Nevian, T.*, Larkum, M.E.*, Polsky, A., Schiller, J. (2007) Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nature Neuroscience, 10: 206-214. * Equal contribution
2006
2005
Ross, W.N., Nakamura, T., Watanabe, S., Larkum, M., Lasser-Ross, N. (2005) Synaptically activated Ca2+ release from internal stores in CNS neurons. Cellular and Molecular Neurobiology, 25: 283-285.
2004
Larkum, M.E., Senn, W, and Lüscher, H.-R. (2004). Top-down dendritic input increases the gain of layer 5 pyramidal neurons. Cerebral Cortex, 10: 1059-70.
Hasan, M.T., Friedrich, R.W., Euler, T., Larkum, M.E., Giese, G., Both, M., Duebel, J., Waters, J., Bujard, H., Griesbeck, O., Tsien, R.Y., Nagai, T., Miyawaki, A., Denk, W. (2004) Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control. PLoS Biol. 2: 763-775.
Larkum, M.E., Watanabe, S., Nakamura, T., Lasser-Ross, N., and Ross, W.N. (2003). Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons. Journal of Physiology 549: 471-488.
2003
Schaefer, A.T., Larkum, M.E., Sakmann, B. & Roth, A. (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. Journal of Neurophysiology 89: 3143-3154.
Waters, J., Larkum, M.E., Sakmann, B. & Helmchen, F. (2003) Supralinear Ca2+ influx into dendritic tufts of layer 2/3 neocortical pyramidal neurons in vitro and in vivo. Journal of Neuroscience 23: 8558-8567.
2002
Larkum, M.E. & Zhu, J.J. (2002) Distal and terminal dendrites of rat layer 5 pyramidal neocortical neurons: initiation and propagation of action potentials in apical tuft branches. Journal of Neuroscience 22: 6991-7005.
London, M., Shribman, A., Häusser, M., Larkum, M.E., Segev, I. (2002) Synaptic information efficacy: Bridging the cleft between biophysics and function. Nature Neuroscience 5: 332-340.
2001
Larkum, M.E., Zhu, J.J., Sakmann, B. (2001) Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons. Journal of Physiology 533: 447-466.
2000
Berger, T.*, Larkum, M.E.* and Lüscher, H.-R. (2000) A high Ih channel density in the distal apical dendrite of layer V neocortical pyramidal cells increases bidirectional attenuation of EPSPs. Journal of Neurophysiology 85: 855-868.
* Equal contribution
1999
Larkum, M.E., Kaiser, K.M.M., Sakmann, B. (1999b) Calcium electrogenesis in distal apical dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action potentials. PNAS. 96: 14600-14604.
1998
Larkum, M.E., Launey, J., Dityatev, A., Lüscher, H.-R. (1998). Integration of excitatory postsynaptic potentials in dendrites of motoneurons of rat spinal cord slice cultures. Journal of Neurophysiology. 80, 924-935
Lüscher, H.-R. & Larkum, M.E. (1998). Modeling action potential initiation and back-propagation in dendrites of cultured rat motoneurons. Journal of Neurophysiology 80, 715-729 (1998).
1996
Larkum, M.E., Rioult, M.G., Lüscher, H.-R. (1996). Propagation of action potentials in the dendrites of neurons from rat spinal cord slice cultures. Journal of Neurophysiology. Vol. 75: 154-170.
Senn, W., Wyler, K., Streit, J., Larkum, M.E., Lüscher, H.-R., Merz, F., Mey, H., Müller, L., Steinhauser, D., Vogt, K. and Wannier, T. (1996). Dynamics of a random neural network with synaptic depression. Neural Networks. 9: 575-588.
1994
Larkum, M.E., Warren, D.A., Bennett, M.R. (1994). Calcium concentration changes in the calyciform nerve terminal of the avian ciliary ganglion after tetanic stimulation. Journal of the Autonomic Nervous System. 46: 175-188.