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Humboldt-Universität zu Berlin - LARKUM LAB

Robert Sachdev , Ph.D.

A central goal of neuroscience is to understand how synaptic inputs are transformed into output, i.e. spiking. My earlier work has shown the effect of background spontaneous activity on the response of cortical neurons.  In my work with Matthew Larkum, I expect to develop methods for watching the transformation of activity in inputs – axons – into an output i.e. activity in dendrites and soma of cortical neurons.  In the course of these observations, we will develop methods for monitoring behavior in multiple dimensions including footfall, whisker movement, touch and cortical state.

 

Education and Training

 

BS in Neuroscience and Biochemistry, University of Michigan, Ann Arbor, MI USA.

                       

PhD in Neuroscience, University of Michigan, Ann Arbor, MI USA

Advisors: Wayne Aldridge and Sid Gilman co-directors

 

1991-1994  MFA in Creative Writing, Columbia University, New York, NY, USA.

1995-2000  Post-doctorate training, Vanderbilt University, Nashville, TN, USA

                  Advisor: Ford Ebner

2000-2004  Post-doctorate training University of Texas San Antonio, Texas, USA

                  Advisor: Charles J. Wilson

 

Academic Employment

 

2005-2014      Associate Research Scientist Yale University School of

                      Medicine, Department of Neurobiology, New Haven, CT, USA.

2004-2005      Assistant Professor, Universite Laval, Quebec, Canada.

2000-2004      Postdoctoral Research Fellow, University of Texas at San Antonio,                       San Antonio, Texas, USA.

1995-2000      Postdoctoral Research Fellow, Vanderbilt University, Nashville, TN,                       USA.

 

Seminars & Invited Presentations

~ 50 invited presentations

 

Completed and ongoing collaborations:

Mark Andermann, Harvard.  2012-2013.  Use of microprisms for imaging from cortical columns.  We published one article in 2013.

 

Hal Blumenfeld, Josh Motelow. Yale School of Medicine, Dept of Neurology. Neurophysiology/Epilepsy.  2010-2014.  Paper under review.

 

Ken Catania, Vanderbilt University 1999-2000.  We published two articles.

 

Detlef Heck, UTHSC in Tennessee, Neurophysiology / Behavior. 2010-2012. We published a paper in the Journal  of Neuroscience (2012).

 

David Kleinfeld, UCSD.  1999-2002.  We published two articles in 2000-2004.

 

Michael Levene, Yale School of Medicine, Dept. of Biomedical Engineering, 2010-2013. We published one article in 2013.

 

James Mazer, Yale School of Medicine.   2012-2013. One published paper.

 

Vincent Pieribone, Yale School of Medicine, Dept  of  Physiology. 2008-2013. One published paper.

 

Gordon Shepherd, Yale School of Medicine, Department of Neurobiology. 2007-2012 The paper from this collaboration was published in J. Neuroscience.

 

Yuguo Yu, Yale School of Medicine.  2007-Current. One paper published in 2014.

 

Hitten Zaveri, Yale School of Medicine.  2012-Current.  Paper under review.

 

Bibliography

 

1.     Sachdev RNS, Gaspard N , Gerrard JL, Hirsch LJ, Spencer D, and  Zaveri HP.  2015. Delta rhythm in wakefulness: evidence from intracranial recordings in human beings.  J. Neurophysiology.

2.     Yu Y, J. Karbowski, R.N.S. Sachdev, J. Feng (2014) Effect of temperature and glia in brain size enlargement and origin of allometric body-brain size scaling in vertebrates BMC Evolutionary Biology 2014, 14:178.

3.     Zagha, E., A. Casale, R.N.S. Sachdev, M. McGinley, and D. A. McCormick. (2013) Motor cortex feedback influences sensory processing by modulating network state. Neuron 79:567-78.

4.     Andermann, M*, N. Gilfoy*, G. Goulding,* R. N. S. Sachdev*, C. Reid, D. A. McCormick, M. Levene. (2013) In vivo two photon microscopy of all neocortical layers. Neuron 80: 900–913.

5.     Sachdev, R.N.S., Krause M. and Mazer J. (2012) Surround Suppression and sparse coding in visual and Barrel Cortices.  Front. Neural Circuits. 6. 43. (Review article).

6.     Cao, Y., Roy S., Sachdev R. N. S., Heck D. (2012) Dynamic correlation between whisking  and breathing rhythms in mice. J. Neurosci. 32, 1653-1659

7.     Phillips, M., Sachdev R. N. S., Willhite D., Sheperd G. (2012) Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb. J. Neurosci. 32, 85-98.  

8.     Davis, D., Sachdev R. N. S., Pieribone V. (2011) “Effect of high velocity, large amplitude stimuli on the spread of Depolarization in S1 “Barrel” Cortex. Somatosens Mot Res. 1-13.

9.     Ros, H., Sachdev R. N.S.*, Yu Y, Sestan N. and McCormick  D. A. (2009) Neocortical  networks entrain neuronal circuits in cerebellar cortex.  J. Neurosci 29: 10309-10320.  

10.     Hasenstaub, A., Sachdev R N.S.*, and McCormick D. A. (2007) Effect of recurrent cortical activity on cortical responses. J. Neurosci. 27: 9607-9622.  *Equal first author.

11.  Melzer, P., Sachdev R. N. S., Jenkinson, N., and Ebner F. F. (2006) Stimulus frequency processing in awake rat barrel cortex. J. Neurosci. 26:12198-12205.

12.  Sachdev R. N. S., Ebner F.F., Wilson C.J. (2004) Response variability in somatosensory cortex: the role  of sub-threshold  Up  and  Down  States.  J. Neurophys.  92:3511-3521

13.  Wilson, C.J., Sachdev R.N.S.  (2004) Intracellular and juxtacellular filling of neurons for studies of axonal projections of individual neurons. Current protocols Neuroscience Suppl. 26 1.12.1-1.12-10.

14.  Sachdev, R.N.S, Berg R., Champney G.C., Kleinfeld D. and Ebner F.F.   (2003) Unilateral vibrissa contact: changes in amplitude but not timing of rhythmic whisking. Somatosens. Mot. Res. 20:163-169.

15.  Sachdev, R.N.S., Champney G.C., Lee H., Price R.R., Pickens D.R., Morgan V.L., Melzer P., Ebner F.F. (2003) Repeated functional magnetic resonance imaging of somatic sensory cortex in the unanesthetized rat. Neuroimage 19:742-750.

16.  Sachdev, R.N.S., Catania K.C. (2002) Effects of stimulus duration on neuronal response properties in the somatosensory cortex of the Star Nosed Mole. Somatosens. Mot. Res. 19:272-278.

17.  Kleinfeld D., R.N.S. Sachdev, Merchant L.M., Jarvis M.R., Ebner F.F. (2002) Adaptive filtering of vibrissa input in motor cortex of rat. Neuron 34, 1024-1034.

18.  Sachdev, R.N.S., Catania  K.C. (2002) Receptive  fields and response properties  of neurons in the star-nosed mole’s somatosensory fovea. J. Neurophysiol. (Cover) 87, 2602-2611.

19.  Sachdev  R.N.S., Sato  T.,  Ebner  F.F.  (2002)  Divergent   movement   of  adjacent   whiskers.   J. Neurophysiol. 87, 1440-1448.

20.  Sachdev R.N.S., Sellien H., Ebner F.F. (2001) Temporal organization  of multi-whisker  contact in rats. Somatosens Mot Res. 18, 91-100.

21.  Harvey M.A., Sachdev R.N.S., Zeigler H.P. (2001) Cortical barrel field ablation and unconditioned whisking kinematics. Somatosens Mot Res.18, 223-227

22.  Sachdev, R.N.S., Sellien H., Ebner F.F.  (2000) Direct inhibition evoked by whisker stimulation in somatic sensory (SI) barrel field cortex of the awake rat. J. Neurophysiol. 84,1497-1504.

23.  Sachdev, R.N.S., Egli M., Stonecypher M., Wiley R. G., Ebner F. F. (2000) Enhancement of cortical plasticity by behavioral training in acetylcholine-depleted adult rats. J. Neurophysiol. 84,1971-1981.

24.  Ebner, F.F., Rema V., Sachdev R.N.S., Symons F.J. (1998) Activity dependent plasticity  in adult somatic sensory cortex. Seminars in Neuroscience, 94, 47-58.

25.  Sachdev, R.N.S., Lu S.M., Wiley R.G., Ebner F. F. (1998) Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity. J. Neurophysiol.79, 3216-3228.

26.  Sachdev, R.N.S., Gilman S., Aldridge J.W.  (1991) Bursting properties of units in cat globus pallidus and entopeduncular nucleus: The effect of excitotoxic striatal lesions, Brain Res., 549, 194-204.

27.  Sachdev, R.N.S., Gilman S., Aldridge J.W. (1989) Effects of excitotoxic  striatal lesions on single unit activity in globus pallidus and entopeduncular nucleus of the cat, Brain Res., 501, 295-306.

28.  Sachdev, R.N.S., E. Jenkinson, H.P. Zeigler and F.F. Ebner (2001) Sensorimotor plasticity in the rodent vibrissa system, in Mutable Brain. Ed. Jon Kaas, pp 123-164.

Society for Neuroscience Abstracts  ~45