Humboldt-Universität zu Berlin - Learning from Alzheimer's Disease

Humboldt-Universität zu Berlin | Projekte | Learning from Alzheimer's Disease | Archiv der Neuigkeiten | Introducing Scope Validity: A Tool for Building New Bridges Across the Translational Gap?

Introducing Scope Validity: A Tool for Building New Bridges Across the Translational Gap?

Vortrag von Lara Keuck im zweiten Treffen des internationalen Netzwerk PhilInBioMed, Bordeaux, FR.
  • Wann 14.10.2019 00:00 bis 15.10.2019 23:59 (Europe/Berlin / UTC200)
  • Termin zum Kalender hinzufügen iCal

Im Oktober 2019 hält Lara Keuck einen Vortrag mit dem Titel "Introducing Scope Validity: A Tool for Building New Bridges Across the Translational Gap?" im zweiten Treffen des internationalen Forschungsnetzwerks PhilInBioMed in Bordeaux, FR.

 

Abstract:

The traditional epistemology of translational medicine adheres to a sequential and separate order. Biomedical researchers first explore candidate targets of intervention in mechanistic animal-based preclinical studies. The results are then extrapolated to humans and tested in randomized controlled clinical trials. A large part of these clinical studies yield negative results. In drug research and development, the difficult step from bench to bedside has been called the ‘valley of death’ or ‘translational gap’. In my talk, I take a closer look at one source of this gap: the mismatch between what qualifies as disease within different areas of research and application—from animal models to general health care. Drawing on examples where this problem is particularly evident, I introduce ‘scope validity’ as a conceptual tool to connect various local measures of validity in a way that makes divergences in identifying a disease transparent. This meta-perspective shall serve to collect, compare, bring into dialogue, and refine existing practices of validation that challenge the traditional sequential order of translational medicine. I will discuss how my interactions with biomedical scientists have informed this project so far and the challenges and possibilities to create impact.